研究论文

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Weng H#, Huang H#, Wu H#, Qin X#, Zhao BS#, Dong L#, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M*, He C*, and Chen J*.  Cell Stem Cell 2018, 22: 191-205. (IF: 23.290)

PMID:29290617

Full Text Link


Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Huang H#, Weng H#, Zhou K#, Wu T#, Zhao BS#, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu Y-C, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan J-L, Qu L, Wei M, Muschen M, Huang G*, He C*, Yang J*, and Chen J*. Nature 2019, 567:414-419. (IF: 41.577)

PMID: 30867593

Full Text Link


FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase

Li Z#, Weng H#, Su R#, Weng X#, Zuo Z#, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X, Zhang P, Jin J, He C*, Chen J*.  Cancer Cell 2017, 31:127-141. (IF: 22.844)

PMID:28017614

Full Text Link


Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability

Huang H#, Weng H#, Sun W#, Qin X#, Shi H#, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S,  Skibbe J, Su R, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C*, Yang J*, Chen J*. Nature Cell Biology 2018, 20:285-295. (IF: 19.064)

PMID:29476152

Full Text Link


Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S

Weng H#, Huang H#, Dong B, Zhao P, Zhou H*, Qu L*. Cancer Research 2014, 74: 4409-4419. (IF:9.130)

PMID:24872388

Full Text Link


Translational repression of cyclin D3 by a stable G-quadruplex in its 5’ UTR: implications for cell cycle regulation

Weng H#, Huang H#, Zhao P, Zhou H*, Qu L*. RNA Biology 2012, 9: 1099-1109. (IF: 5.216)

PMID:22858673

Full Text Link


Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growth inhibition and apoptosis

Huang H#, Weng H#, Wang L, Yu C, Huang Q, Zhao P, Wen J, Zhou H*, Qu L*. Molecular Cancer Therapeutics 2012, 11: 1155-1165. (IF: 5.365)

PMID:22389469

Full Text Link


Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia

Huang H#, Weng H#, Dong B, Zhao P, Zhou H*, and Qu L*. Scientific Reports 2017, 7: 41525. (IF: 4.122)

PMID:28128329

Full Text Link


Overexpression and knockout of miR-126 both promote leukemogenesis

Li Z#*, Chen P#, Su R#, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, and Chen J*.  Blood 2015; 126: 2005-2015.

PMID:26361793

Full Text Link


Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles

Jiang X#*, Bugno J#, Hu C, Yang Y, Herold T, Qi J, Chen P, Gurbuxani S, Arnovitz S, Strong J, Ferchen K, Ulrich B, Weng H, Wang Y, Huang H, Li S, Neilly MB, Larson RA, Le Beau MM, Bohlander SK, Jin J, Li Z, Bradner JE, Hong S*, and Chen J*. Cancer Research 2016; 76: 4470-4480.

PMID:27280396

Full Text Link


PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease

Li Z#, Chen P#, Su R#, Hu C#, Li Y, Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S, Huang H, Neilly MB, Wang GG, Jiang X, Liu PP, Jin J, and Chen J*. Cancer Research 2016; 76: 619-629.

PMID:26747896

Full Text Link


miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Jiang X, Hu C, Arnovitz S, Bugno J, Yu M, Zuo Z, Chen P, Huang H, Ulrich B, Gurbuxani S, Weng H, Strong J, Wang Y, Li Y, Salat J, Li S, Elkahloun AG, Yang Y, Neilly MB, Larson RA, Le Beau MM, Herold T, Bohlander SK, Liu PP, Zhang J, Li Z, He C, Jin J, Hong S, and Chen J*. Nature Communications 2016; 7: 11452.

PMID:27116251

Full Text Link


Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia

Huang H, Jiang X, Wang J, Li Y, Song CX, Chen P, Li S, Gurbuxani S, Arnovitz S, Wang Y, Weng H, Neilly MB, He C, Li Z, and Chen J*. Cancer Letters 2016; 372: 157-165.

PMID:26791235

Full Text Link


Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Jiang X#*, Hu C#, Ferchen K, Nie J, Cui X, Chen CH, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J, Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy J, Zheng Y, Diao J, Jin J, Liu PP, Chen Y, and Chen J*. Nature Communications 2017; 8: 2099.

PMID:29235481

Full Text Link


R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling

Su R#, Dong L#, Li C#, Nachtergaele S#, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J*, He C*, and Chen J*.  Cell 2018; 172: 90-105. Highlighted (Research Watch) by Cancer Discovery (2018 Feb;8(2):137).

PMID:29249359

Full Text Link


RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia

Shen C#, Sheng Y#, Zhu AC#, Robinson S#, Jiang X#, Dong L#, Chen H#, Su R, Yin Z, Li W, Deng X, Chen Y, Hu Y-C, Weng H, Huang H, Prince E, Cogle CR, Sun M, Zhang B, Chen C-W, Marcucci G, He C*, Qian Z*, Chen J*.  Cell Stem Cell 2020, 27: 64-80.

PMID:32402250

Full Text Link


Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Su R#, Dong L#, Li Y#, Gao M#, Han L#, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robinson S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Kulkarni P, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen M, Muschen M, Marcucci G, Salgia R, Li L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J*. Cancer Cell 2020, 38:79-96.

PMID:32531268

Full Text Link


综述论文

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

Zeng C#, Huang W#, Li Y*, Weng H*Journal of Hematology & Oncology 2020, 13:117.

PMID:32854717

Full Text Link


RNA N6-Methyladenosine Modification in Normal and Malignant Hematopoiesis

Weng H, Huang H, Chen J. Leukemia Stem Cells in Hematologic Malignancies, 2019: 75-93. Springer, Singapore.

Full Text Link


The Biogenesis and Precise Control of RNA m6A Methylation

Huang H#, Weng H#, Chen J.  Trends in Genetics 2019, 36: 44-52.

PMID:31810533

Full Text Link


m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Huang H#, Weng H#, Chen J. Cancer Cell 2020, 37: 270-288.

PMID:32183948

Full Text Link


RNA Modifications in Cancer: Functions, Mechanisms, and Therapeutic Implications

Huang H, Weng H, Deng X, Chen J. Annual Review of Cancer Biology 2020, 4: 221-240.

Full Text Link


The pathological role and prognostic impact of miR-181 in acute myeloid leukemia

Weng H, Lal K, Yang F, Chen J. Cancer Genetics 2015, 208: 225-229.

PMID:25686674

Full Text Link


Attacking c-Myc: Targeted and Combined Therapies for Cancer

Huang H#, Weng H#, Zhou H*, Qu L*. Current Pharmaceutical Design 2014, 20: 6543-6554.

PMID:25341931

Full Text Link


RNA N6-methyladenosine modification in cancers: current status and perspectives

Deng X*, Su R, Weng H, Huang H, Li Z, Chen J*. Cell Research 2018, doi:10.1038/s41422-018-0034-6.

PMID:29686311

Full Text Link


已授权专利

1) 翁桁游,黄慧琳,屈良鹄,周惠。miR-17-5p 及 miR-20a 在制备依托泊苷耐药逆转剂中的应用。中国,授权公告日:2016-01-27;专利号:ZL201310274073.5

2) 翁桁游,黄慧琳,屈良鹄,周惠。冬凌草甲素联合依托泊苷在制备抗肿瘤药物中的应用。中国,授权公告日:2016-08-10;专利号:ZL201310274073.5

3) 翁桁游,黄慧琳,屈良鹄,周惠。冬凌草甲素在制备 FBW7 抑癌蛋白激活剂中的应用。中国,授权公告日:2013-08-28;专利号:ZL201110413556.X.